Genes induced by HIF
MDR:Multidrug resistance is the ability of pathologic cells to withstand chemicals that are designed to aid in the eradication of such cells. These pathologic cells include bacterial and neoplastic (tumor) cells
Hypoxia increases cell proliferation rate through reduction of glucose oxidative breakdown and induction of many enzymes (Glutamine synthetase, Glycolytic enzymes, G6PD etc). The high fetal growth rate is at least partially dependent on low fetal pO 2 .