GSH peroxidases (GPX)
Glutathione (GSH)

Author: Gianpiero Pescarmona
Date: 16/08/2019

Description

DEFINITION

Glutathione peroxidase (GPx) (EC 1.11.1.9) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. The biochemical function of glutathione peroxidase is to reduce different peroxides (H2O2, lipid peroxides) using GSH as a reducing agent.

2GSH + H2O2 GSSG + 2H2O

Glutathione reductase then reduces the oxidized glutathione to complete the cycle:

GSSG + NADPH + H+ → 2 GSH + NADP+.

THE GENE

DatabaseLink
HGNC"GPX1":"GPX2":"GPX3":"GPX4":"GPX5":"GPX6":"GPX7":"GPX8":
Uniprot"GPX1":"GPX2":"GPX3":"GPX4":"GPX5":"GPX6":"GPX7":"GPX8":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

  • Primary structure
  • Secondary structure
  • Tertiary structure
  • Quaternary structure


Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Protein Aminoacids Percentage (Width 700 px)

SYNTHESIS AND TURNOVER

mRNA synthesis

gpx and vitamin D

protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

GPX4

cellular localization,
biological function

  • Enzymes
DatabaseLink
BRENDA - The Comprehensive Enzyme Information System"URL":
KEGG Pathways"URL":
Human Metabolome Database"URL":
  • Cell signaling and Ligand transport
  • Structural proteins

REGULATION

DIAGNOSTIC USE

Attachments
fileuserdate
GPX_1-8.pnggp22/08/2019
AddThis Social Bookmark Button