Protein Arginine Methyltransferases (PRMT)
Methylation

Author: Gianpiero Pescarmona
Date: 20/05/2010

Description

DEFINITION

Protein arginine methyltransferases (PRMT) catalyze methylation of nitrogen of specific arginine residues in proteins.

Type I and II PRMTs both catalyze monomethylation of the guanidinium (ω) nitrogen of specific arginine residues in proteins;

  • Type I PRMTs modify proteins by the catalysis of asymmetric NG,NG-dimethylarginine
  • Type II PRMTs catalyze the formation of symmetric NG,N′G-dimethylarginine.
  • Type III enzymes catalyze only the monomethylation of arginine residues in proteins

Protein Arginine Methyltransferases: from Unicellular Eukaryotes to Humans 2007

DatabaseLink
WikigenesPRMT1; PRMT2; PRMT3; Carm1/PRMT4; PRMT5; PRMT6; PRMT7; PRMT8; FBXO11/ PRMT9
WikipediaPRMT1; PRMT2; PRMT3; PRMT4; PRMT5; PRMT6; "PRMT7":; "PRMT8":; "PRMT9":
GeneCards"PRMT1":; "PRMT2":; "PRMT3":; "PRMT4":; "PRMT5":; "PRMT6":; "PRMT7":; "PRMT8":; "PRMT9":

Asimmetric dimethyl arginine

Attachments
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PRMT1_600.gifgp20/05/2010
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