Protein -SH group modification
Proteins Post-translational Modifications

Author: Gianpiero Pescarmona
Date: 23/11/2020

Description

Protein -SH groups may undergo different types of modification either reversible or irreversible:

  • Oxidation to disulfide bridges
    *

Il basso livello di GSH si accompagna a modificazioni dei gruppi -SH delle proteine

Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration, 2019 Fulltext

Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration, 2020

Anethole trithione

Anethole trithione

Anethole+trithione+and+liver

Comparison of various aryl-dithiolethiones and aryl-dithiolones as hydrogen sulfide, H2S, donors in the presence of rat liver microsomes. 2020

It has been reported that the formation of H2S from the metabolism of anetholedithiolethione (ADT, Sulfarlem) and anetholedithiolone (ADO) by liver microsomes mainly derived from their oxidation by cytochrome P450 (CYP)-dependent monooxygenases, and that ADO was a better H2S-donor than ADT under these conditions.

Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a. 2016

We observed that, paradoxically, Nrf2 protein levels decline in the livers of aged rats despite the inflammatory environment evident in that organ.

Anethole dithiolethione lowers the homocysteine and raises the glutathione levels in solid tissues and plasma of rats: a novel non-vitamin homocysteine-lowering agent. 2014

Concomitantly, glutathione (GSH) increased between 112% and 28% in kidneys, brain, liver and plasma whereas protein thiolation index decreased 30%.

Comments
2020-11-28T13:28:59 - Gianpiero Pescarmona
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