paola+costelli+il-15
Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control, 2001
While IL-15 did not cause changes in either muscle mass or muscle protein content, it induced significant changes in the fractional rates of both muscle protein synthesis and degradation, with no net changes in protein accumulation. Additionally, IL-15 administration resulted in a 33% decrease in white adipose tissue mass and a 20% decrease in circulating triacylglycerols; this was associated with a 47% lower hepatic lipogenic rate and a 36% lower plasma VLDL triacylglycerol content. The decrease in white fat induced by IL-15 was in adipose tissue.
Protein Aminoacids Percentage (Width 700 px)
Glu/Gln alto (2.5)
Cortisolo basso?
Comparison of the Effects of 8 Weeks of Complex Training and HMB Supplements on IL-15 Levels, Cortisol, and Some Physiological and Functional Variables of Male Basketball Players,
Abstract
Beta-hydroxy beta-methyl butyric acid (HMB) was able to upregulated anabolic agents and downregulated catabolic agents, and it can affect the benefits of physical activities. Therefore, the purpose of this study was to examine the effect of 8 weeks of Complex Training (Resistance+ polymeric) and HMB supplements on IL-15, Cortisol, lipid profile, body composition and performance of Basketball Players. 40 basketball club players were randomly divided into four groups of 10, including: 1. Control group, 2. Supplementary group (HMB), 3. Complex training group, and 4. Training group + Supplement (HMB). The training program was performed for 8 weeks, 3 sessions per week and each session for 1.5 hours with intensity 60-80% 1RM. Serum levels of interleukin 15, cortisol, lipid profiles were taken one day before and 48 hours after the exercise protocol was performed in fasting blood. Data were analyzed by dependent sample T-test and two-way ANOVA (P <0.05). Regarding the results of two-way ANOVA, the main effect of exercise in all variables except cortisol was significant. In addition, the main effect of HMB supplementation was significant only in two variable of medicine ball throwing (F = 11.08, p = 0.002) and vertical jump (F = 62.22, p = 0.001). Complex training with HMB supplementation has the greatest effect on increasing anabolic responses (increased IL-15) and reducing catabolic responses (Cortisol) and lipid profile indexes. Therefore, it seems that use of this supplement with the complex training modality is effective in improving physiological conditions and enhancing explosive power athletes such as basketball.
Serum interleukin-15 levels in cancer patients with cachexia, 2012
Abstract
Interleukin-15 (IL-15) has important anabolic effects on muscle protein metabolism through a decrease in the ATP-ubiquitin-dependent proteolytic pathway. The role of IL-15 in human cancer cachexia is unknown. The aim of this study was to assess the relationship between interleukin-15 (IL-15) in cancer patients with cachexia at diagnosis of malignancy and 8 weeks later. An observational study of 21 cancer patients (with and without cachexia) and 8 healthy subjects was conducted. Body composition was measured by leg-to-leg impedance. Serum IL-15 levels were assessed at baseline and after 4 and 8 weeks. Baseline IL-15 values were similar in cancer patients and in healthy subjects. Cancer patients with lower baseline levels of IL-15 (<2 pg/ml) had significantly higher fat mass (%) along the study. Eighteen patients completed the study: five patients showed an increase of 3.7 kg at the end of the study (5.4% of body weight) and showed a mean increase of IL-15 of 1.32 pg/ml (121%) at 4 weeks and 2.32 pg/ml (197%) at 8 weeks, as compared with mean decrease of -4.1 kg (-5.3%) and -0.09 pg/ml (-2.5%) and 0.6 pg/ml (40.8%) in the 13 patients who lost weight (P=0.001 and P=0.022, respectively). Changes of IL-15 at 4 and 8 weeks were directly associated with changes in body weight, body mass index (BMI), fat-free mass and muscle mass (P<0.05), and indirectly associated with percentage of weight loss (P<0.05). In summary, although the results indicate that IL-15 does not have a role in cancer cachexia pathogenesis, the association during evolution between serum IL-15 and changes in weight and muscle mass suggests a possible role of IL-15 as a marker of the body composition response in cancer patients who are losing weight at the time of diagnosis.
