The disease definition according to a specific consensus conference or to The Diseases Database based on the Unified Medical Language System (NLM)
Also the link to the corresponding Mesh term has to be created
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degenerative disc disease
age, sex, seasonality, etc
PATIENT RISK FACTORS
TISSUE SPECIFIC RISK FACTORS
anatomical (due its structure)
vascular (due to the local circulation)
physiopathological (due to tissue function and activity)
Genet Test Mol Biomarkers. 2010 Mar 31;: 20367178
Association of the Polymorphisms of Vitamin D Receptor and Aggrecan Genes with Degenerative Disc Disease.
Betul Eser, Tulin Cora, Olcay Eser, Erdal Kalkan, Alpay Haktanır, Mujgan O Erdogan, Mustafa Solak
1 Department of Medical Genetic, Faculty of Meram Medicine, Selcuk University , Konya, Turkey .
The aim of this study was to investigate the association between the polymorphisms of vitamin D receptor (VDR) and aggrecan genes and degenerative disc disease in young Turkish patients. Aggrecan and VDR proteins are the main components of bone and cartilage. In our study, the polymorphisms of VDR and aggrecan genes were investigated in a total of 300 individuals regarding disc degeneration and herniation. An association was found in the patients having VDR gene TT, Tt, FF, and Ff genotypes with the protrusion type of disc herniation, whereas the patients having tt and ff genotypes were associated with extrusion/sequestration types of the disease. Also, an association was observed between TT and FF genotypes of VDR gene and mild forms of disc degeneration; and tt, ff, and Ff genotypes and severe forms of the disease. There was also an association between shorter, normal, and longer alleles of the aggrecan gene and a protrusion type of disc herniation. An association was found between short alleles and multilevel and severe disc degeneration, as well as normal and long alleles and mild disc degeneration. This study revealed that the polymorphisms of VDR and aggrecan genes are associated with disc degeneration and herniation.