Immune System

Author: Gianpiero Pescarmona
Date: 06/08/2010


The innate and adaptive immune systems and the overlap between them.

Central and peripheral tolerance mechanisms.

Co-stimulatory and co-inhibitory molecules set thresholds for T-cell activation.

Regulation of LCK tyrosine kinase activity by PTPN22 and CSK.

T-cell receptor (TCR) crosslinking leads to dephosphorylation of the tyrosine kinase LCK at Y505 by the membrane phosphatase CD45. Subsequent autophosphorylation of LCK at Y394 is an early event in T-cell activation, leading to phosphorylation (P) of downstream substrates by LCK. The tyrosine phosphatase PTPN22 and the intracellular kinase CSK both negatively regulate LCK by removal of the activating phosphate at Y394 (PTPN22) and rephosphorylation of Y505 (CSK). PTPN22 polymorphisms (R620W) have been shown to disrupt the binding of PTPN22 to CSK, and to increase the intrinsic phosphatase activity of PTPN22 itself.

Model of innate immune responses in autoimmunity.

Activation of interferon production through TLR7 and TLR9 receptors.

Sibling risk and HLA associations for selected autoimmune disorders
Non-HLA susceptibility genes for autoimmune disease

from Genetics of autoimmune diseases — disorders of immune homeostasis 2006

Differences between immune response to Virus and bacteria (LPS)

Innate immune response gene expression profiles of N9 microglia are pathogen-type specific 2006 Fulltext

from, 2001

The history of Toll-like receptors — redefining innate immunity, 2013

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