Vesicular Stomatitis Virus (VSV)

Author: Gianpiero Pescarmona
Date: 04/02/2018


Vesicular stomatitis Indiana virus is a virus in the family Rhabdoviridae; the well-known rabies virus belongs to the same family. VSIV can infect insects, cattle, horses and pigs. It has particular importance to farmers in certain regions of the world where it can infect cattle. This is because its clinical presentation is identical to the very important foot and mouth disease virus.

VSIV is an arbovirus, and its replication occurs in the cytoplasm and therefore is dependent only from amino acids availability and ATP.

The genome of VSIV is on a single molecule of negative-sense RNA that has 11,161 nucleotides in length,4 that encodes six major proteins: G protein (G), large protein (L), phosphoprotein, matrix protein (M), nucleoprotein and Protein C

Protein Aminoacids Percentage (Width 700 px)

All VSIV proteins require:

TrP : 2%
Pro: 4/6%

C_VSIVA0.400May play a role in viral pathogenesis or transmission by insects vectors
NCAP_VSIVA1.214Encapsidates the genome in a ratio of one N per nine ribonucleotides, protecting it from nucleases
GLYCO_VSIVA1.389Attaches the virus to host LDL receptors, inducing clathrin-dependent endocytosis of the virion
L_VSIVA1.600RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs
PHOSP_VSIVA1.938Essential component of the RNA polymerase transcription and replication complex
MATRX_VSIVA4.333Assembly and budding of virion

The proteins are listed on the basis of the Glu/Gln ratio that correlates with the evolutionary age.

Regulation of Virus Replication

It is inhibited by:

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