COVID-19 and Bradykinin

Author: Gianpiero Pescarmona
Date: 02/09/2020


A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm, 2020 july

bradykinin and COVID-19

Bradykinin induces ROS production

bradykinin and ROS

ROS and Kallikrein-kinin

kallikrein and ROS

Early activation of bradykinin B2 receptor aggravates reactive oxygen species generation and renal damage in ischemia/reperfusion injury. 2006

Reactive oxygen species (ROS), malondialdehyde, and reduced/oxidized glutathione measurement revealed that the oxidative stress was augmented by kallikrein administration in both ischemic and reperfusion phases.

Taurine modulates kallikrein activity and glucose metabolism in insulin resistant rats. 2002

Urinary kallikrein activity was higher in taurine-treated animals than in the rats fed only fructose.

alternative GSH effect on the Bradykinin pathway?

bradykinin and glutathione

The specificity of potentiating effect of glutathione on the actions of bradykinin 1979

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