Author: Gianpiero Pescarmona Date: 18/03/2007
Purines and Pyrimidines Synthesis L. Stryer
Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis 2001
The Phosphatidylinositol 3-Kinase/Akt Cassette Regulates Purine Nucleotide Synthesis 2009
Mutational analysis of conserved glycine residues 142, 143 and 146 reveals Gly142 is critical for tetramerization of CTP synthase from Escherichia coli
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The relationship between purines, pyrimidines, nucleosides, and glutamine for fibroblast cell proliferation. 1984
Virginia.edu
Synthesis of glutamine, glycine and 10-formyl tetrahydrofolate is coregulated with purine biosynthesis in Saccharomyces cerevisiae, 1998
Glutamine, glycine and 10-formyl tetrahydrofolate are consumed during de novo purine biosynthesis. We have found that, in Saccharomyces cerevisiae, synthesis of these cosubstrates is coregulated with synthesis of enzymes of the purine biosynthetic pathway. Analysis of three genes required for synthesis of glutamine, glycine and 10-formyl tetrahydrofolate (GLN1, SHM2 and MTD1, respectively) shows that their expression is repressed by adenine and requires the transcription factors Bas1p and Bas2p. Northern analysis reveals that regulation of SHM2 and MTD1 expression by adenine takes place at the transcriptional level.
