DEFINITION
DMT1 (also known as natural resistance-associated macrophage protein 2 NRAMP2 , divalent cation transporter 1 DCT1 , or solute carrier family 11 member 2 SLC11A2 ) is a transporter involved in human iron metabolism. It is located on the apical membrane of duodenal enterocytes and transports Fe2+ from the intestinal lumen to the cytosol.
Dietary iron must be reduced from Fe3+ to Fe2+ before being transported by DMT1.
CHEMICAL STRUCTURE AND IMAGES
When relevant for the function
- Primary structure
- Secondary structure
- Tertiary structure
- Quaternary structure
SYNTHESIS AND TURNOVER
mRNA synthesis
protein synthesis
post-translational modifications
degradation
CELLULAR FUNCTIONS
cellular localization,
biological function
- Enzymes
- Cell signaling and Ligand transport
- Structural proteins
REGULATION
DIAGNOSTIC USE
