Author: Gianpiero Pescarmona
Steroid sulfatase is an enzyme involved in the metabolism of steroids. It is encoded by the STS gene at the locus Xp22.32
X-linked recessive ichthyosis occurs in about 1 in 6,000 males studied in various populations
Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in rheumatoid arthritis synovial cells: a prerequisite for local androgen deficiency., 2005
These data indicate that TNF inhibits the conversion of DHEAS to DHEA in RA synovial cells. Because androgens are antiinflammatory mediators, TNF-induced inhibition of the local androgen supply is a supplementary proinflammatory factor.