The AGC [cAMP-dependent protein kinase (PKA)}protein kinaseG}protein kinase C (PKC)] protein kinase extended family embraces a collection of protein kinase families that display a high degree of primary sequence conservation within their respective kinase domains (see The Protein Kinase Resource Classification). Outside these catalytic domains, the AGC protein kinases generally show little similarity.
This lack of regulatory domain conservation re¯ects the very distinct controls that operate on
these proteins.
