Glucose Metabolism

Author: Gianpiero Pescarmona
Date: 22/08/2010


amiloride glucose-6-phosphate phosphatase

Gluconeogenesis is a reverse process of glycolysis. In gluconeogenesis, the pyruvates and related three and four carbon compounds are converted back to glucose.

In human body, the starting materials for gluconeogenesis are three carbon compounds, including * lactate, pyruvate, glycerol*, and certain amino acids. The process happens mainly in liver. The glucose produced through gluconeogenesis passes into blood to supply the fuel to other tissues. As an example, after intensive physical exercise, lactate produced by anaerobic glycolysis in skeletal muscle returns to the liver and is converted to glucose with the gluconeogenesis. The glucose is sent to muscle through blood circulation. In muscle, the glucose is converted into glucogen. This circuit is called Cori cycle.

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