Interleukin 1
Interleukins

Author: Gianpiero Pescarmona
Date: 23/01/2011

Description

DEFINITION

A short protein description with the molecular wheight, isoforms, etc...
Use, when available, the link to Wikipedia (Es Trypsin)

The original members of the IL-1 superfamily are IL-1α, IL-1β, and the IL-1 Receptor antagonist (IL-1RA).
IL-1α and -β are pro-inflammatory cytokines involved in immune defense against infection.
The IL-1RA is a molecule that competes for receptor binding with IL-1α and IL-1β, blocking their role in immune activation.

THE GENES

DatabaseLink
WikigenesIL1AIL1BIL1RA
GeneCards"IL1A":"IL1B":"IL1RA":
Your Favorite Gene Sigma"IL1A":"IL1B":"IL1RA":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

  • Primary structure
  • Secondary structure
  • Tertiary structure
  • Quaternary structure


h4. Protein Aminoacids Percentage

Arginine is higher in IL1RA, the inhibitor of IL1Receptor.

Anti-inflammatory role of arginine??

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

  • Enzymes
DatabaseLink
BRENDA - The Comprehensive Enzyme Information System"URL":
KEGG Pathways"URL":
Human Metabolome Database"URL":
  • Cell signaling and Ligand transport
  • Structural proteins

REGULATION

DIAGNOSTIC USE

Attachments
fileuserdate
IL1A-IL1B-ILRA-CH1.gifgp23/01/2011
IL1AIL1B-ILRA-CH2.gifgp23/01/2011
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