cAMP
cAMP is synthesized from ATP by the action of Adenylyl-Cyclase
cAMP is degraded to AMP by a Phosphodiesterase
The level of cAMP depends on the balance of the 2 enzymes activities.
Adenylyl-Cyclase
how many and why?
Type 1, 7, 5, 6
Type 2
Type 3, 8
Association with MRP1. MRP4. MRP5. MRP.
CNNM4= Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions By similarity. May play a role in biomineralization and retinal function.
Type 4
Type 9
Type 10 (ABCYA)
TRPA1: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system By similarity.
Enzyme regulation
Inhibited by ruthenium red, a otent blocker of TRPV channels By similarity.
cAMP-Phosphodiesterase
how many and why?
