Insulin Superfamily

Author: Gianpiero Pescarmona
Date: 05/02/2013


The insulin/IGF/relaxin family is a group of evolutionary related proteins which possess a variety of hormonal activities. Family members in human include two subfamilies:

  1. insulin and insulin-like growth factors
  2. relaxin family peptides
    • relaxin 1 and 2
    • relaxin 3
    • Leydig cell-specific insulin-like peptide (gene INSL3)
    • early placenta insulin-like peptide (ELIP) (gene INSL4)
    • insulin-like peptide 5 (gene INSL5)
    • insulin-like peptide 6
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