Clathrin-mediated Endocytosis
Acid Vesicles

Author: Gianpiero Pescarmona
Date: 10/01/2018


Clathrin-coated vesicles (CCV) selectively sort cargo at the cell membrane, trans-Golgi network, and endosomal compartments for multiple membrane traffic pathways. After a vesicle buds into the cytoplasm, the coat rapidly disassembles, allowing the clathrin to recycle while the vesicle gets transported to a variety of locations.

AP-2 complex is formed by different proteins

Clathrin is a protein that plays a major role in the formation of coated vesicles.

Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium (By similarity)

APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.

, 2017

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Effect of high intratesticular estrogen on global gene expression and testicular cell number in rats. 2010

To confirm the microarray data, we chose randomly six differentially expressed genes (estradiol up- and down-regulated genes), namely topoisomerase (DNA) 2 alpha (Top2a), nitric oxide synthase 3, endothelial cell or eNOS (Nos3), carboxyesterase3 (Ces3), ENA Vasodilator Phosphoprotein (Evl), adaptor-related protein complex 2, sigma 1 subunit (*Ap2S1, -2.04 Fold change*), and retinoblastoma (Rb1).

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