GSH and Environmental Pollution
Glutathione (GSH)

bats+and+glutathione

Bats GSH is decreased by pesticides et al.

lowering+gsh

parathion lower, NAC restores acetylcholinesterase

Air Pollution

Air pollution and case fatality of SARS in the People's Republic of China: an ecologic study, 2003

Air pollution seen acting on stress hormones, 2017

Genetic Variation in the Glutathione Synthesis Pathway, Air Pollution, and Children's Lung Function Growth, 2011

Air pollution may reduce body GSH, and low level of GSH are associated with different symptoms, including insulin resistance and diabetes, one of the death risk factors in Covid19 infected patients:

• Persistent organic pollutants as risk factors for type 2 diabetes. 2015
  Although obesity is considered to be the main driver of the pandemic of T2DM, a possible contribution of some environmental contaminants, of which persistent organic pollutants (POPs) form a particular class, has been suggested.

• Persistent Organic Pollutants, Endogenous Hormones and Diabetes in Latinos, 2016
  Several studies have shown significant associations of diabetes with persistent organic pollutants (POPs), including organochlorine pesticides, polychlorinated biphenyls (PCBs), and brominated flame retardants (BFRs).

• The effect of occupational exposure on pro/antioxidant balance in the blood of non-smoking and smoking smelters with diabetes.2016

• Can persistent organic pollutants explain the association between serum gamma-glutamyltransferase and type 2 diabetes? 2007
  The results of several epidemiological studies of serum gamma-glutamyltransferase (GGT) led us to hypothesize that associations of GGT within its normal range with type 2 diabetes may reflect detrimental effects of xenobiotics found in the environment, such as persistent organic pollutants (POPs)

• Hormesis and public health: can glutathione depletion and mitochondrial dysfunction due to very low-dose chronic exposure to persistent organic pollutants be mitigated? 2014
  Noting that regulation of POPs, while critical, has provided insufficient protection because POPs persist in human bodies and the food chain, advantageous stressors should be used by the public to mitigate glutathione depletion and mitochondrial dysfunction due to POPs.

Pesticides

glyphosate+and+glutathione

Drugs

Arachidonic acid alleviates the detrimental effects of acetylsalicylic acid on human granulosa cells performance in vitro. 2020
ASA treatment reduced E2 production, Cyp19a1 expression, glutathione peroxidase (GPx) activity, and estradiol receptor expression in CGCs.
h3. Diet