GSH depletion by drugs
Glutathione (GSH)

Author: Gianpiero Pescarmona
Date: 28/03/2020



acetaminophen and doxorubicin (adriamycin), isoproterenol
antimalarial drugs, chloroquine, etoposide

Intracellular glutathione in human hepatocytes incubated with S-adenosyl-L-methionine and GSH-depleting drugs. 1991
GSH depletion found in human hepatocytes incubated with GSH-depleting drugs (paracetamol, opiates, ethanol).



Differential induction of NF-kappaB activity and neural cell death by antidepressants in vitro. 2010

The exposure to these drugs led to increased generation of reactive oxygen species and a concomitant reduction of intracellular glutathione levels.

Metabolic mechanisms of drug-nutrient interactions. 1985
Prooxidant drugs such as chloroquine, drugs detoxified by conjugation with glutathione, and alcohol can deplete reduced glutathione with consequent effects on amino acid transport and the redox status of cells.

Ibuprofen administration attenuates serum TNF-alpha levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation. 2008

The combined inhibition of COX-1 and COX-2 by ibuprofen attenuates TNF-alpha secretion, glutathione depletion, mitochondrial alterations, hepatic apoptosis and mortality in Jo2-treated fasted mice.

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