GSH fibrosis
Glutathione (GSH)

Author: Gianpiero Pescarmona
Date: 03/04/2020


Role of glutathione biosynthesis in endothelial dysfunction and fibrosis.


  • Endothelial haplo-insufficiency of GCLc increases basal and stimulated ROS levels.
  • Decreased endothelial GSH promotes eNOS S-glutathionylation.
  • Endothelial GSH reduction impairs endothelium-dependent vasodilation in male mice.
  • Reduced endothelial GSH levels promotes renal fibrosis.
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