The precursors
There is a cross-regulation between AMP and GMP synthesis: ATP is required for GMP synthesis and vice versa
From Monucleotide to Dinucleotide
All the 3 enzymes lack TrP pointing to a function alternative to cell proliferation (???)
From the evolutionary point of view (Glu/Gln low to high): KGUA-->KAD1 (cytoplasm)-->KAD2 (mitochondria)
AMP as a signal
In non-reproducing cells, like muscle and nerve, the balance between ATP, ADP, and AMP mainly relies on Ox-Phos activity, and an AMP increase corresponds to a low energy balance
Adenylate Kinase and AMP Signaling Networks: Metabolic Monitoring, Signal Communication and Body Energy Sensing, 2009
See AMPK
All enzymes involved in reactions from AMP to ATP have no Trp (antagonists to proliferation??)
