Protein -SH groups may undergo different types of modification either reversible or irreversible:
- Oxidation to disulfide bridges
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Il basso livello di GSH si accompagna a modificazioni dei gruppi -SH delle proteine
Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration, 2019 Fulltext
Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration, 2020
Anethole trithione
Anethole trithione
Anethole+trithione+and+liver
Comparison of various aryl-dithiolethiones and aryl-dithiolones as hydrogen sulfide, H2S, donors in the presence of rat liver microsomes. 2020
It has been reported that the formation of H2S from the metabolism of anetholedithiolethione (ADT, Sulfarlem) and anetholedithiolone (ADO) by liver microsomes mainly derived from their oxidation by cytochrome P450 (CYP)-dependent monooxygenases, and that ADO was a better H2S-donor than ADT under these conditions.
Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a. 2016
We observed that, paradoxically, Nrf2 protein levels decline in the livers of aged rats despite the inflammatory environment evident in that organ.
Anethole dithiolethione lowers the homocysteine and raises the glutathione levels in solid tissues and plasma of rats: a novel non-vitamin homocysteine-lowering agent. 2014
Concomitantly, glutathione (GSH) increased between 112% and 28% in kidneys, brain, liver and plasma whereas protein thiolation index decreased 30%.
