One Symptom Many Causes

Author: Gianpiero Pescarmona
Date: 23/09/2020


GABA and bradycardia

Modification of cardiovascular responses to spinal GABA receptor stimulation by cAMP and by K(ATP) channel blockade in anaesthetized rats. 1999
Pretreatment with 8-bromo-cAMP (10 nmol), a cAMP analogue, attenuated the depressor and bradycardic effects of baclofen (100 nmol), but not with 8-bromo-cGMP (10 nmol), a cGMP analogue.

Value of diazepam ('Valium') in treatment of cardiac arrhythmias. 1970

In 3 out of 38 patients with atrial flutter the use of diazepam was followed by an increase in atrioventricular block.

The role of the sympathetic nervous system in the cardiovascular effects of systemically administered gamma-aminobutyric acid. 1984":
Pretreatment with reserpine (1 mg/kg, i.m.) or ganglionic blockade with hexamethonium (10 mg/kg, i.v.) plus atropine (1 mg/kg, i.v.) abolished the GABA-induced hypotension and bradycardia.

Possible azithromycin-associated hiccups. 2005

Discontinuation of azithromycin and therapy with baclofen finally resolved hiccups.

Bradycardia and Hypothermia Complicating Azithromycin Treatment. 2017

A sigmoid Emax pharmacokinetic/pharmacodynamic model suggested a maximal azithromycin-associated reduction in heart rate of 23 beats/minute.

heart rate and Azithromycine


QT prolongation with hydroxychloroquine and azithromycin for the treatment of COVID-19: The need for pharmacogenetic insights. 2020

Bradycardia and capsaicin

Cardiovascular responses elicited by intrathecal kinins in the conscious rat. 1992

The bradycardia was converted to tachycardia by prazosin, atropine, pentolinium, capsaicin and in spinal transected rats.

Substance P?



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