One Symptom Many Causes

Author: Gianpiero Pescarmona
Date: 02/04/2021


Mild hypoglycemia is a common feature in cognitive impairment

TNF-α and hypoglycemia

Dexamethasone attenuates hypoglycemia in ten day old rats treated with TNF alpha. 1996

TNF alpha induced hypoglycemia and lactacidemia without altering plasma insulin concentration in 10 day old rats.

Parallel relationship between the increase in serotonin in the liver and the hypoglycaemia induced in mice by interleukin-1 and tumour necrosis factor. 1991

In the present study, it was found that the cytokines produced by macrophages in response to LPS, interleukin-1 (IL-1, 0.1 microgram/kg or more) and tumour necrosis factor (TNF alpha, 100 micrograms/kg or more), can also induce an increase in liver serotonin and produce hypoglycaemia.

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