ABC-transporter
Membrane Transport

Author: Gianpiero Pescarmona
Date: 18/02/2010

Description

Kegg Pathway

DEFINITION

ATP-binding cassette transporters (ABC-transporter) are members of a protein superfamily that is one of the largest and most ancient families.
They are transmembrane proteins that utilize the energy of adenosine triphosphate (ATP) hydrolysis to carry out certain biological processes including:

  • translocation of various substrates across membranes (metabolic products, lipids and sterols, and drugs)
  • non-transport-related processes such as translation of RNA and DNA repair

Proteins are classified as ABC transporters based on the sequence and organization of their ATP-binding cassette (ABC) domain(s).

ABC transporters are involved in tumour resistance, cystic fibrosis, bacterial multidrug resistance, and a range of other inherited human diseases.

MAMMALIAN ABC TRANSPORTERS IN HEALTH

AND DISEASE 2002

External links not available on Wikipedia have to be added here

DatabaseLink
WikigenesURL
GeneCards"URL":
iHOP"URL":
Entrez Gene"URL":
OMIM"URL":
OMIM Gene map"URL":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

  • Primary structure
  • Secondary structure
  • Tertiary structure
  • Quaternary structure


Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Model (Width 600 px)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis
post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

  • ABC-importer

  • ABC-exporter

  • Enzymes
  • Cell signaling and Ligand transport
  • Structural proteins

REGULATION

DIAGNOSTIC USE

ABC_transporter W

Transporter specificity

MDR1

49 Human ATP-Binding Cassette Transporters

Attachments
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2013table_ABC.gifmassimiliano.boero16/02/2014
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