Sphingosylphosphorylcholine and its Receptor
Lipids Signaling

DEFINITION

Sphingosylphosphorylcholine Receptor

GPR68

THE GENE

Database	Link
HGNC	ACADM
Uniprot	"URL":

HGNC includes links to

• BioGPS
• GENATLAS
• GeneCards
• GOPubmed
• H-InvDB
• QuickGO
• Reactome
• Wikigenes includes links to
  • NCBI
  • NCBI SNP
  • iHOP resource
  • OMIM
  • UniProt
  • Ensembl
  • HGNC

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

• Primary structure
• Secondary structure
• Tertiary structure
  • PDB
• Quaternary structure

Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Protein Aminoacids Percentage (Width 700 px)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

• Enzymes

Database	Link
BRENDA - The Comprehensive Enzyme Information System	"URL":
KEGG Pathways	"URL":
Human Metabolome Database	"URL":

• Cell signaling and Ligand transport
• Structural proteins

REGULATION

Boehringer Ingelheim is looking for a partner that can identify novel and relevant disease indications for a potent and selective preclinical GPR68 (ORG1) antagonist.

DIAGNOSTIC USE