Authors: Tatchim Kapoko kevin & Deumo Deumo Aurelien Quentin
INTRODUCTION
known medically as malignant neoplasia, is a large group of diseases involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, which may invade nearby parts of the body. It is accepted by most oncologists that cancer has ,hidden several years of life before being detected.Dr. André Gernez developed in the 1970s a Therapy of active prevention of cancers whose essential principle is the destruction of cancer cells as they arise and before they can form a detectable and difficult to cure cancer.To achieve this goal and the result effectively prevent the occurrence of cancer of all types, regardless of their location (artery, brain, pancreas, lung, prostate, kidney, breast, etc..) And whatever their causes (genetics, pollution, smoking, etc..) recommends a course of 40 days, starting from the age of risk that is to say about 35 years and renew every year to destroy each year nascent cancer cells in the body and make impossible the formation and development of a cancerous tumor.
Fonte: cure anti-cancer
THE THERAPY'S STEPS
The following Collins Curve, allow us to understand the interest of acting at the onset of cancer cells and not to expect the formation of a detectable tumor:
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The treatment period should be long enough, so that the majority of cells in the body has time to go through a divisional phase, and the cell division takes place, specifically in anticancer conditions and also so that the action on the mutated cells can occur. This period corresponds biologically to 40 days.The best time to practice anti-cancer treatment is in the early spring or late winter . It is especially essential for people of both sexes aged 35- 40 to 70 years, according to what emerges from the observation of the curve of cancer mortality. Considering that it takes 7 to 8 years between the birth of the first cell and the emergence of clinical cancer, it would be unwise to wait until the age characterizes high cancer mortality. Before this age, the risk of cancer is statistically low (except in predestined groups by the profession, and except inheritance, etc..). After 70 years, cancer mortality is declining in favor of other causes ... the cure fight elsewhere, too, though not specifically.
The treatment consists of three main parts: an initial phase based on food reduction,diet, then a supplementation with vitamins and trace elements, and in the final phase, the destruction of cancer cells by taking anti-cancer and anti-mitotic drugs in very low dose.
The essential elements of the anti-cancer treatment are:
1) a- Significant reduction in daily food intakes liable to cause weight loss (3 - 5% of the body weight). This undernourishment tends to settle in the body a state of metabolic acidosis, an extremely unfavorable condition to cancer cells , a phenomenon that is triggered outside of pathological states, only by fasting or prolonged fever (Note that muscular exercise is supported by the acidification of lactic generator that causes muscle and is also an unfavorable environment to cancer, which is practically unknown) This also tends to create a reduction of the metabolism that can be complemented appropriate medication and taking dietary supplements under medical control. For sedentary people it is preferable to have one meal a day instead of doing a quantitative reduction of various meals , because acidosis is caused faster. Restrictions will focus on sugar in all its forms , is the specific food of the cancer cell ( avoid artificial sweeteners , honey can be used in moderation) . The restrictions also cover the meat undercooked or barbecued and all cholesterol-rich foods (eggs , butter, fatty cheeses , dairy , shellfish , animal fat, crushed . ) On food products made from highly sifted flour ( bread white , pastries, usual pasta, etc. . ) on refined oils called " table " and margarine or other hydrogenated vegetable fats . These products will be replaced by lesser amounts of the corresponding natural foods. Wholemeal bread, brown rice, acid fruits and dried fruits, low fat cheese, virgin olive oil , unrefined sea salt
warburg was the first to make the observation and explanation. From a
degree of acidification, cancer can not use the sugar that it
needs.
Statistics show that the world record non-cancerous are
held by groups of people who distinguish themselves by a record periods
acidosis, regardless of origin:
- Living conditions (malnutrition)
- Eating habits (monastic)
- Disease: uremia, arteriosclerosis: in arteriosclerotic (in whom
abnormal hypermagnésinémie is also constant), the rate of
carcinogenesis password from 35.7% to 18.7%.
-social habits (some Asian populations)
b- Oxygenation: We look for anything that promotes breathing and oxygenation of the body, especially the forest walks, mountain and near the sea, and all physical activity outdoors (unpolluted): gymnastics breathing, eating foods rich in vitamin C (citrus fruits), ozonation air in the apartments. Correspondingly, we avoid anything that affects the oxygenation of the body, eg stay vitiated atmosphere or confined, smoking, sedentary lifestyle.We have long known that " if it occurs in a tissue , any cause which deprives oxygen , the cells that are
able to feed by fermentation remain alone. In this way is selection between cells
will not only continue to live ,but will also develop more actively " ( Warburg ) . However, these cells
that can make do without oxygen ,replacing it by fermentation , are cancer cells.
Correction of hypoxia (decreased oxygen in the tissues) is a factor that promote normal cells.
2) taking supplements vitamins and trace elements
supply with vital substances :vitamins(C,A,E); trace elements: selenium, magnesium; zinc, aliments rich in diastase, these are essential for the normal cell and necessary for self-defense of the body against abnormal cells. These substances can be found in an appropriate taking of supplements , and can also be abundantly provided by an enriched diet of fresh fruits, various vegetables, wholemeal bread , virgin pressed vegetable oils ... , However magnesium is particularly important because it is essential for all cells
the body so that their divisions are performed normally, whereas cancer cells can perform divisions
with catalyser of substitution.Why this magnesium deficiency has general implications ?
When we consider the scheme for the synthesis of RNA ( ribonucleic acid , one of the two acids are observed in
cell nuclei ) , a striking feature of the observer. At almost every stage of the diagram, we see the
Mg letters . This is magnesium . It is necessary for that organizes RNA terminal. But RNA is acid that regulates
cell division . Magnesium is directly involved in the cells normally perform their division.
Is it missing? The division performs all the same, but worse. The cell will proceed by substituting this
natural catalyst ersatz : potassium , for example. This substitution does not interfere with the cancer cell division which is much less difficult and can use other less quality catalyser, contrarily to normal cells
. A magnesium deficiency is therefore a factor especially
favorable to all cancer cells in the body of the cell selection,.magnesium deficiency is a fact that is widespread and many physicians prescribe it. Given the important role of this catalyst for healthy cells prevalence over cancer cells, it is necessary to ensure adequate fixation in the body. Food intake can be more than enough if we had a permanent use of products that are rich of it. But the diet may not be enough to fill a deficiency in few weeks , especially as cell attachment and recharge this catalyst is very slow. That is why it is important first to exclude the use of alcohol during the treatment ( alcohol opposes magnesium fixation) .
c. It should also be avoided in this treatment the factors that promote cancer cells, in particular:
- Blood donation , which stimulates cell division
- The corticosteroid therapy
- Tobacco , alcohol , and dangerous chemical additives , synthetic dyes , preservatives ( nitrite ) , synthetic flavorings and flavor enhancers ( glutamate)
- In case of chronic organ disease, curing period should be adapted and include the best as possible functional rest of that organ . Gastritis , colitis, bronchitis, etc. . Often neglected because rebels to curative treatment, must be given special attention , even if temporary , to alleviate the burden placed on remaining healthy cells , especially as chronic diseases are the bed of cancer.
3. Hunting terminal micro- cancers :
The last day of the cure period is the direct destruction by anticancer drugs , abnormal cells that could withstand the natural extinction when the cell is restored habitat in a status that does not lend itself to survive. This purge residual embryos have reduced to a few cancer cells (16 on average at the end of the first year of evolution) , which still pollute bodies , complete cleaning of the body. We have seen that involves the use of anticancer drugs at a very low dose ( the dose required to destroy cancer is proportional to the number of cells it contains and this dose , stage a dozen cells is negligible ) . The use of these anticancer drugs (also used for other diseases such as chronic arthritis or psoriasis ) may, however, represent , by their abuse or wrong dosage , a toxic hazard and therefore a clear formulation and to review by the physician.
The basic protocol: start at the age of 40 and if possible in March:
1) - 25 days of food reduction, with patronage (usual dose) of vitamin C and E, magnesium,
selenium and a small dose of acetylsalicylic acid (aspirin 250 mg per day). Other trace elements and vitamins
can be added chromium, cobalt, silicon ...
this stage of active prevention must involve methods of oxygenation.
2) - 8 day period with the use of colchicine (1mg/jour) which ensures the blocking of cell division phase.
3) - 3 day period with a product that boosts cell division (cortisone)
4 )- period of 2 to 3 days with a slight antimitotic, eg chloral hydrate (50 mg 3 times a day 3 days).
5)- the treatment has to be repeated annually.
DO WE HAVE CONFIRMATION OF SUCH A METHOD?
The answer is yes. Here are some facts that corroborate.
- When giving anticancer drugs to a lot of animals
we intentionally cancérise then, the number of cancers observed
collapses. This is the case for instance of certain strains of mice which
carcinogenesis of the breast occurs spontaneously, even without being provoked,
in over 95% of the females. If the animals are subjected to products
anticancer, 80% of them escape such a fate.
- In humans, evidence of the effectiveness of this method is provided by a
fortuitous observation that mentally ill inmates. These patients have
long been the fraction of the population less affected by cancer.
However, they were administered as a sedative chloral hydrate, which is
be a minor anticancer product. Schizophrenics, most subject to
this medication, the canceration rate was reduced to the point that no
never discerned cancer in them. Since the cancellation of this medication in
benefit of neuroleptics (1950) this fraction of the population has gradually
found the incidence of cancer in the general population.
Tratto da POUR UNE POLITIQUE PUBLIQUE DE PREVENTION ACTIVE DU CANCER
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ADVANTAGES OF THE THERAPY.
a) it is a low cost therapy that clearly could help many countries where cancer has a big incidence, to save many lives and a lot of money, by investing in prevention rather than spending,in expensive therapies that are unefficient in certain types of cancer like leucemiae, brain cancer,mesothelioma, and other cancer when they are diagnosed very late.
b) You are sure to attack, in its first phase, a potential cancer in formation, when it is very
vulnerable because there are still a limited number of cells. This rule is essential.
If, for any reason, survived the treatment some cells, they would be destroyed the following year when
they would be very vulnerable
The threshold of irreversibility of the cancer is about 1 million cells , and this treshold is reached after an average of 5-6
years from the appearance of the first cancer cell. A cancer in formation is 5 or 6 times at the risk of being destroyed by the annual cures and this is a very wide safety margin.
c)Many oncologists agree to notice the influence of moral factors in the genesis of cancer, this takes
from the fact that emotions and moral distress are generating alkalosis. The treatment tends to correct this effect by systematized acidification
d) Magnesium
Magnesium is an essential element in biological systems. Magnesium occurs typically as the Mg2+ ion. It is an essential mineral nutrient (i.e., element) for life and is present in every cell type in every organism. For example, ATP (adenosine triphosphate), the main source of energy in cells, must be bound to a magnesium ion in order to be biologically active. What is called ATP is often actually Mg-ATP. As such, magnesium plays a role in the stability of all polyphosphate compounds in the cells, including those associated with the synthesis of DNA and RNA.In plants, magnesium is necessary for synthesis of chlorophyll and photosynthesis
Over 300 enzymes require the presence of magnesium ions for their catalytic action, including all enzymes utilizing or synthesizing ATP, or those that use other nucleotides to synthesize DNA
Nucleic Acids
Nucleic acids have an important range of interactions with Mg2+. The binding of Mg2+ to DNA and RNA stabilises structure; this can be observed in the increased melting temperature ™ of double-stranded DNA in the presence of Mg2+. In addition, ribosomes contain large amounts of Mg2+ and the stabilisation provided is essential to the complexation of this ribo-protein. A large number of enzymes involved in the biochemistry of nucleic acids bind Mg2+ for activity, using the ion for both activation and catalysis. Finally, the autocatalysis of many ribozymes (enzymes containing only RNA) is Mg2+ dependent (e.g. the yeast mitochondrial group II self splicing introns).
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Magnesium ions can be critical in maintaining the positional integrity of closely clustered phosphate groups. These clusters appear in numerous and distinct parts of the cell nucleus and cytoplasm. For instance, hexahydrated Mg2+ ions bind in the deep major groove and at the outer mouth of A-form nucleic acid duplexes.
The recommended daily intake of magnesium for an adult is 350 mg for men and 300 mg for women (Lichton, 1989), the dose can be increased up to 450 mg during pregnancy and lactation. Magnesium is responsible for many essential metabolic processes such as the formation of urea, the transmission of impulses muscle, nerve transmission and cellular electrical stability
Essential role in the biological activity of ATP
ATP (adenosine triphosphate), the main source of energy in cells, must be bound to a magnesium ion in order to be biologically active. What is called ATP is often actually Mg-ATP.
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e) Selenium
Selenium is a chemical element with atomic number 34. Its symbol is Se. It is a non-metal chemically similar to sulfur and tellurium.
Selenium is a oligonutriente present in nature that is an essential nutrient, which is involved in numerous biological functions . Natural sources of selenium are fish, meat, meat offal, milk and dairy products, yeast, grains, nuts, mushrooms, fruits and vegetables . The selenium in foods is present in inorganic form (as selenite) is in organic form (as selenomethionine and seleniocisteina).
Biological role
Although it is toxic in large doses, selenium is an essential micronutrient for animals. In plants, it occurs as a bystander mineral, sometimes in toxic proportions in forage (some plants may accumulate selenium as a defense against being eaten by animals, but other plants such as locoweed require selenium, and their growth indicates the presence of selenium in soil). See more on plant nutrition below.
Selenium is a component of the unusual amino acids selenocysteine and selenomethionine. In humans, selenium is a trace element nutrient that functions as cofactor for reduction of antioxidant enzymes, such as glutathione peroxidases and certain forms of thioredoxin reductase found in animals and some plants (this enzyme occurs in all living organisms, but not all forms of it in plants require selenium).
The glutathione peroxidase family of enzymes (GSH-Px) catalyze certain reactions that remove reactive oxygen species such as hydrogen peroxide and organic hydroperoxides:
2 GSH + H2O2----GSH-Px → GSSG + 2 H2O
Selenium also plays a role in the functioning of the thyroid gland and in every cell that uses thyroid hormone, by participating as a cofactor for the three of the four known types of thyroid hormone deiodinases, which activate and then deactivate various thyroid hormones and their metabolites: the iodothyronine deiodinases are the subfamily of deiodinase enzymes that use selenium as the otherwise rare amino acid selenocysteine. (Only the deiodinase iodotyrosine deiodinase, which works on the last break-down products of thyroid hormone, does not use selenium).
Selenium may inhibit Hashimoto's disease, in which the body's own thyroid cells are attacked as alien. A reduction of 21% on TPO antibodies was reported with the dietary intake of 0.2 mg of selenium.
Increased dietary selenium intakes reduce the effects of mercury toxicity and it is now recognized that the molecular mechanism of mercury toxicity involves irreversible inhibition of selenoenzymes that are required to prevent and reverse oxidative damage in brain and endocrine tissues.
Evolution in biology
Main article: Evolution of dietary antioxidants
From about three billion years ago, prokaryotic selenoprotein families drive the evolution of selenocysteine, an amino acid. Selenium is incorporated into several prokaryotic selenoprotein families in bacteria, archaea and eukaryotes as selenocysteine, where selenoprotein peroxiredoxins protect bacterial and eukaryotic cells against oxidative damage. Selenoprotein families of GSH-Px and the deiodinases of eukaryotic cells seem to have a bacterial phylogenetic origin. The selenocysteine-containing form occurs in species as diverse as green algae, diatoms, sea urchin, fish and chicken. Selenium enzymes are involved in utilization of the small reducing molecules glutathione and thioredoxin. One family of selenium-containing molecules (the glutathione peroxidases) destroy peroxide and repair damaged peroxidized cell membranes, using glutathione. Another selenium-containing enzyme in some plants and in animals (thioredoxin reductase) generates reduced thioredoxin, a dithiol that serves as an electron source for peroxidases and also the important reducing enzyme ribonucleotide reductase that makes DNA precursors from RNA precursors.
Trace elements involved in GSH-Px and superoxide dismutase enzymes activities, i.e. selenium, vanadium, magnesium, copper, and zinc, may have been lacking in some terrestrial mineral-deficient areas. Marine organisms retained and sometimes expanded their seleno-proteomes, whereas the seleno-proteomes of some terrestrial organisms were reduced or completely lost. These findings suggest that, with the exception of vertebrates, aquatic life supports selenium utilization, whereas terrestrial habitats lead to reduced use of this trace element.Marine fishes and vertebrate thyroid glands have the highest concentration of selenium and iodine. From about 500 Mya, freshwater and terrestrial plants slowly optimized the production of "new" endogenous antioxidants such as ascorbic acid (Vitamin C), polyphenols (including flavonoids), tocopherols, etc. A few of these appeared more recently, in the last 50–200 million years, in fruits and flowers of angiosperm plants. In fact, the angiosperms (the dominant type of plant today) and most of their antioxidant pigments evolved during the late Jurassic period.
The deiodinase isoenzymes constitute another family of eukaryotic selenoproteins with identified enzyme function. Deiodinases are able to extract electrons from iodides, and iodides from iodothyronines. They are, thus, involved in thyroid-hormone regulation, participating in the protection of thyrocytes from damage by H2O2 produced for thyroid-hormone biosynthesis. About 200 Mya, new selenoproteins were developed as mammalian GSH-Px enzymes.
.The recommended daily intake of selenium in the adult of both sexes is 55 micrograms per day
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f) Zinc
Zinc is a chemical element with atomic number 30. Its symbol is Zn.Zinc is an essential trace element, present in the organism in quantities greater than any other trace element apart from iron.
Zinc is an essential trace element in the life of humans and the higher animals: a zinc deficiency seriously affects body growth and weight gain. The zinc constitutes parts of protein with zinc fingers and enzymes with antioxidant action such as superoxide dismutase, or with catalytic functions such as carbonic anhydrase, the alcohol dehydrogenase, and lactate dehydrogenase, enter in the constitution of at least 20 enzymes. Zinc is a cofactor that interfers ,in many biological functions and therefore participates in protein synthesis including DNA and RNA; The formation of the fetus and his weight gain ;As a necessary element for the moltiplication and cellular maturation during wound healing. Zinc is also involved in the operation of sight, smell, touch and memory, and is responsible for the good functioning of these, and a zinc deficiency will cause malfunctions.
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Metallothionein 1G and zinc sensitize human colorectal cancer cells to chemotherapy.
Metallothioneins (MTs) are a family of low molecular-weight proteins that are silenced during colorectal cancer progression, mainly through epigenetic mechanisms, and this loss is associated with poor survival. In this article, we show that overexpression of the MT1G isoform sensitizes colorectal cell lines to the chemotherapeutic agents oxaliplatin (OXA) and 5-fluorouracil (5-FU), in part through enhancing p53 and repressing NF-B activity. Despite being silenced, MTs can be re-induced by histone deacetylase inhibitors such as trichostatin A and sodium butyrate. In fact, this induction contributes to the cytotoxicity of these agents, given that silencing of MTs by siRNAs reduces their growth-inhibitory activities. Zinc ions also potently enhance MTs expression, and are also cytotoxic to cancer cells. We show for the first time that OXA and 5-FU induce higher levels of intracellular labile zinc, as measured using the fluorescent probe FLUOZIN-3, and that such zinc contributes to the activation of p53 and repression of NF-B. Addition of zinc enhanced growth inhibition by OXA and 5-FU, and was also capable of re-sensitizing 5-FU resistant cell lines to levels comparable to sensitive cell lines. This effect was metallothionein- independent, since silencing MTs did not affect zinc cytotoxicity. In conclusion, we show that MTs induction and zinc administration are novel strategies to sensitize colorectal cancer cells to presently utilized chemotherapeutic agents.
tratto da Pubmed
DISADVANTAGES OF THE THERAPY
a)the diet is rather restrictive. and may run into obstacles such as the fact of rhythms, and habits of life in urban areas, which expose us to every days to so many polluted air,with a nutrition not always healthy, very sweet, very oily, salty,with many preservatives substances, pesticides and other chimicals used in agricuture and in the food industry , available in supermarkets . the Inactivity. And the fact that it is difficult to find natural products recommended for the diet
b) The supplements in vitamins and trace elements, can be toxic if they are taken in a very high dose. The use of anticancer active prevention can obviously only be
performed under medical supervision, as it implements the use of
substances which, when improperly dosed or mismanaged, would not be without
inconvenience.
c) the use of cortisone at the end of therapy to restart the mitosis, poses some problems,One of the potentially harmful effects of cortisone, however, is to suppress the immune system (a possible explanation of the correlation between stress and illness).The immunosuppression instead of helping to fight against microcancers, could have the opposite effect ,and help the micro-cancer to continue to moltiplicate.
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d)more than 400 micrograms per day of selenium can cause poisoning by selenium (selenosis).
e)Excessive intake of zinc in the diet can cause deficiencies of other trace elements.
A large epidemiological study of 47,000 men showed an increase in prostate cancer for zinc supplements (not for the food source) is taken in doses of 100 mg / day for prolonged periods (from 1 to 10 years), more in proportion the duration of the assumption that the dose
The dose was much higher in the zinc requirements of an adult, which is calculated as 0.1 mg / kg / day. Zinc stimulates growth hormone IGF1 and testosterone, and high doses locks the protective role of selenium against prostate cancer.
Similarly, zinc is a powerful stimulant for the immune response, but in large doses it weakens.
literary quotations.
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wikipedia
Sorgenti:
-Libro:"POUR UNE POLITIQUE PUBLIQUE DE PREVENTION ACTIVE DU CANCER" Les propositions du Dr André Gernez,nouvelle édition, Dr Jean-Claude Meuriot, Dr Jacque Lacaze.
-www.gernez.asso.fr/cancer-preventif/
-http://www.ncbi.nlm.nih.gov/pubmed/
-http://it.wikipedia.org/wiki/
