Mitochondria and Apoptosis

Author: Gianpiero Pescarmona
Date: 17/04/2020


The sensing of mitochondrial DAMPs by non-immune cells, 2019

Mitochondria are the source of damage-associated molecular patterns (DAMPs), which are molecules that play a key modulatory role in immune cells. These molecules include proteins and peptides, such as N-formyl peptides and TFAM, as well as lipids, and metabolites such as cardiolipin, succinate and ATP, and also mitochondrial DNA (mtDNA). Recent data indicate that somatic cells sense mitochondrial DAMPs and trigger protective mechanisms in response to these signals. In this review we focus on the well-described effects of mitochondrial DAMPs on immune cells and also how these molecules induce immunogenic responses in non-immune cells. Special attention will be paid to the response to mtDNA.

Master Regulator Analysis of the SARS-CoV-2/Human Interactome. 01 04 2020

We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus.

EEF1A1 (Elongation factor 1-alpha 1), which is involved in tRNA delivery to the ribosome, and is known to be activated upregulated upon inflammation [55]

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.

The eEF1A proteins: at the crossroads of oncogenesis, apoptosis, and viral infections, 2015


This effect is blocked by rapamycin, indicating that the increase in EF1A expression is mediated by the mammalian target of rapamycin (mTOR) pathway.

Se serve GTP per la sintesi proteica ribosomale, la mancanza di glutamine dovrebbe bloccare la sintesi del virus


cosi' รจ


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