DEFINITION
Dec2 or BHLHB3 is a Transcriptional Repressor, belonging to the class of basic helix-loop-helix proteins (BHLH)
A short protein description with the molecular wheight, isoforms, etc...
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CHEMICAL STRUCTURE AND IMAGES
When relevant for the function
- Primary structure
- Secondary structure
- Tertiary structure
- Quaternary structure
SYNTHESIS AND TURNOVER
mRNA synthesis
protein synthesis
post-translational modifications
degradation
CELLULAR FUNCTIONS
cellular localization,
biological function
RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes
- Enzymes
- Cell signaling and Ligand transport
- Structural proteins
REGULATION
Altered Stra13 and Dec2 circadian gene expression in hypoxic cells 2008
The circadian system regulates rhythmically most of the mammalian physiology in synchrony with the environmental light/dark cycle. Alteration of circadian clock gene expression has been associated with tumour progression but the molecular links between the two mechanisms remain poorly defined. Here we show that Stra13 and Dec2, two circadian transcriptional regulators which play a crucial role in cell proliferation and apoptosis are overexpressed and no longer rhythmic in serum shocked fibroblasts treated with CoCl2, a substitute of hypoxia. This effect is associated with a loss of circadian expression of the clock genes Rev-erbα and Bmal1, and the clock-controlled gene Dbp. Consistently, cotransfection assays demonstrate that STRA13 and DEC2 both antagonize CLOCK: BMAL1 dependent transactivation of the Rev-erbα and Dbp promoters . Using a transplantable osteosarcoma tumour model, we show that hypoxia is associated with altered circadian expression of Stra13, Dec2, Rev-erbα, Bmal1 and Dbp in vivo. These observations collectively support the notion that overexpression of Stra13 and Dec2 links hypoxia signalling to altered circadian clock gene expression.
Expression of the gene for Dec2, a basic helix–loop–helix transcription factor, is regulated by a molecular clock system 2003
A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation 2003
Circadian rhythms: Finer clock control 2002
DEC1 Modulates the Circadian Phase of Clock Gene Expression 2008
The Clock mutation resulted in extreme reduction of Dec1 expression in kidney, heart, and skeletal muscle but not in liver, whereas it strongly repressed Dec2 expression in liver, kidney, and heart, while Dec2 expression in skeletal muscle remained rhythmic. Per2 also showed the tissue-dependent disruption of the rhythmicity by Clock mutation, whereas rhythmic expression of Dbp in Clock mutant mice disappeared in all tissues examined. Npas2, a structurally and functionally related gene to Clock, showed significant levels of expression in the liver and kidney with a robust rhythmicity, which was also affected by Clock mutation. These marked changes in the Dec1 and Dec2 expression, as well as in the Per2, Dbp, and Npas2 expression in the periphery by Clock mutation, indicated that CLOCK plays a major role in the expression of these genes in most tissues.
Tissue-Specific Disruption of Rhythmic Expression of Dec1 and Dec2 in Clock Mutant Mice 2004
Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism 2008
Effects of Fasting and Re-Feeding on the Expression of Dec1, Per1, and Other Clock-Related Genes 2006
DIAGNOSTIC USE
