Histones
Nucleic Acids Metabolism

Author: Gianpiero Pescarmona
Date: 28/02/2010

Description

Histones undergo a cycle of acetylation/deacetylation that modulate DNA packaging

Proteins AA content offers information about AA content in the niche

  • CLoCK protein has been shown to possess histone acetyltransferase activity, and can acetylate its partner, bmAL1, on lysine 537.
  • The histone deacetylase sirtuin 1 (SIRT1) interacts with CLoCK and can deacetylate lysine 537 of bmAL1 as well as lysine 9 and 14 of histone H3. SIRT1 is expressed in a circadian manner

CLoCK means:

  • glutamine and bases synthesis and switch on DNA synthesis
  • Threonine is pointing to a cell metabolism with high NADPH and ATP

SIRT1 means

  • glutamine and glutamate and acetylCoA and switch off DNA synthesis
Comments
2010-03-08T12:17:08 - Gianpiero Pescarmona

Proteins AA content offers information about AA content in the niche

  • CLoCK protein has been shown to possess histone acetyltransferase activity28, and can acetylate its partner, bmAL1, on lysine 537.
  • The histone deacetylase sirtuin 1 (SIRT1) interacts with CLoCK and can deacetylate lysine 537 of bmAL1 as well as lysine 9 and 14 of histone H3. SIRT1 is expressed in a circadian manner

SIRT1 means glutamine and glutamate and acetylCoA and switch off DNA synthesis

CLoCK means glutamine and bases synthesis and switch on DNA synthesis

Search for the AA % of the 2 proteins. Result

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