Cell Cycle Answers
Niche

Author: Gianpiero Pescarmona
Date: 02/03/2009

Description

Proteins AA content offers information about AA content in the niche

  • CLoCK protein has been shown to possess histone acetyltransferase activity28, and can acetylate its partner, bmAL1, on lysine 537.
  • The histone deacetylase sirtuin 1 (SIRT1) interacts with CLoCK and can deacetylate lysine 537 of bmAL1 as well as lysine 9 and 14 of histone H3. SIRT1 is expressed in a circadian manner

CLoCK means glutamine and bases synthesis and switch on DNA synthesis

Threonine is pointing to a cell metabolism with high NADPH and ATP

SIRT1 means glutamine and glutamate and acetylCoA and switch off DNA synthesis

Attachments
fileuserdate
Cdc7-MCM2--MCM3.gifgp02/03/2009
clock-sirt1.gifgp02/03/2009
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