DEFINITION
A short protein description with the molecular wheight, isoforms, etc...
Use, when available, the link to Wikipedia (Es Trypsin)
External links not available on Wikipedia have to be added here
THE GENE
HGNC includes links to
- BioGPS
- GENATLAS
- GeneCards
- GOPubmed
- H-InvDB
- QuickGO
- Reactome
- Wikigenes includes links to
- NCBI
- NCBI SNP
- iHOP resource
- OMIM
- UniProt
- Ensembl
- HGNC
CHEMICAL STRUCTURE AND IMAGES
When relevant for the function
- Primary structure
- Secondary structure
- Tertiary structure
- Quaternary structure
Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)
Protein Aminoacids Percentage (Width 700 px)
SYNTHESIS AND TURNOVER
mRNA synthesis
protein synthesis
post-translational modifications
degradation
CELLULAR FUNCTIONS
cellular localization,
biological function
- Cell signaling and Ligand transport
- Structural proteins
REGULATION
DIAGNOSTIC USE
MSH effects
Agouti gene
Structures of the Agouti Signaling Protein, 2005
Agouti-signaling_protein
Pleiotropic effects of Agouti Signaling Protein, ASIP
Agouti regulation of adipogenesis: a working model. Increased cortisol, either through the local production of cortisol by 11β-HSD-1 or increased activity of the hypothalamic-ituitary-adrenal axis, leads to increased agouti transcription. Agouti increases both proliferation (by blocking the effects of αMSH) and differentiation (through the upregulation of PPARγ protein).
(Agouti Expression in Human Adipose Tissue. Functional Consequences and Increased Expression in Type 2 Diabetes, 2003)
Model to account for responsiveness to cAMP level in activation but not inactivation of eumelanin synthesis. See Discussion for main explanation. (A-YY) ASIP-YY, (Mc) melanocyte, (Mb) melanoblast, (Ub) ubiquitinylation. Melanocortin-1 receptor (MC1R) is shown with some basal activity (left, lost in e mutant), to explain why POMC null, a/a mice are black, and related data (see text). (This might alternatively be due to BD103 or some unknown signal). Agouti signaling protein (ASIP) would not be required for pheomelanogenesis unless Y has been switched on by the MC1R/cAMP pathway, hence inactive MC1R would give a yellow color even with deficient MGRN1, as seen in e/e, md/md mice.
(Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway. 2009)
