DEFINITION
The WNT gene family consists of structurally related genes which encode secreted signaling proteins interacting with receptors on target cells (Frizzled and LRP families)
THE GENES
| Database | Link | Link | Link | Link | Link | Link | Link | Link | Link |
| Wikigenes | "WNT1": | "WNT2": | "WNT2B": | "WNT3": | WNT3A | "WNT4": | "WNT5A": | "WNT5B": | "WNT6": |
| GeneCards | "WNT1": | "WNT2": | "WNT2B": | "WNT3": | "WNT3A": | "WNT4": | "WNT5A": | "WNT5B": | "WNT6": |
| YFG Sigma | "WNT1": | "WNT2": | "WNT2B": | "WNT3": | "WNT3A": | "WNT4": | "WNT5A": | "WNT5B": | "WNT6": |
| Wikigenes | WNT7A": | "WNT7B": | "WNT8A": | "WNT8B": | "WNT9A": | "WNT9B": | "WNT10A": | WNT10B | "WNT11": |
| GeneCards | "WNT7A": | "WNT7B": | "WNT8A": | "WNT8B": | "WNT9A": | "WNT9B": | "WNT10A": | "WNT10B": | "WNT11": |
| YFG Sigma | "WNT7A": | "WNT7B": | "WNT8A": | "WNT8B": | "WNT9A": | "WNT9B": | "WNT10A": | "WNT10B": | "WNT11": |
| Wikigenes | "WNT16": |
| GeneCards | "WNT16": |
| YFG Sigma | "WNT16": |
CHEMICAL STRUCTURE AND IMAGES
When relevant for the function
- Primary structure
- Secondary structure
- Tertiary structure
- Quaternary structure
Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)
Protein Aminoacids Percentage (Width 700 px)
SYNTHESIS AND TURNOVER
mRNA synthesis
BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. 2008
When BMP signaling is blocked during this latter phase, enforced expression of either Cdx1 or Cdx4 rescues hematopoietic development, thereby placing BMP4 signaling upstream of the Cdx-Hox pathway. Wnt signaling cooperates in BMP-induced hemogenesis, and the Wnt effector LEF1 mediates BMP4 activation of Cdx genes. Our data suggest that BMP signaling plays two distinct and sequential roles during blood formation, initially as an inducer of mesoderm, and later to specify blood via activation of Wnt signaling and the Cdx-Hox pathway.
This signaling is under tight control and is limited by multiple endogenous mechanisms. In one such regulation, Dickkopf proteins (Dkk) bind and promote the internalization of lipoprotein receptor-related protein (LRP)-5 or LRP-6. Blocking these Wnt receptor components effectively downregulates Wnt signaling. Diarra and coworkers have discovered that overexpression of Dkk-1 in RA joints leads to excess inhibition of classical Wnt signaling, and is a critical factor in the bone erosion seen in RA
protein synthesis
post-translational modifications
degradation
CELLULAR FUNCTIONS
cellular localization,
biological function
One mode of signaling pathway regulation occurs at the level of extracellular antagonists that interact with ligands and prevent signaling. The secreted Frizzled-related proteins (sFRP) were the first Wnt antagonists to be identified. the Wnt homepage - Stanford
Canonical and noncanonical Wnt signaling pathways.
Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis 2009
Papers Wnt mTOR
Papers Wnt10B
Papers Wnt10B and Hypoxia
Papers Wnt10b and cadherin
LRP
- Cell signaling and Ligand transport
- Structural proteins
REGULATION
DIAGNOSTIC USE
