B-cell Activating Factor (BAFF)
TNF Family

Author: Gianpiero Pescarmona
Date: 18/03/2014

Description

DEFINITION

B-cell activating factor also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene

THE GENE

DatabaseLink
WikigenesACADM
GeneCards"URL":
Your Favorite Gene Sigma"URL":

Wikigenes includes links to

  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

  • Primary structure
  • Secondary structure
  • Tertiary structure
  • Quaternary structure


Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Protein Aminoacids Percentage (Width 700 px)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

  • Enzymes
DatabaseLink
BRENDA - The Comprehensive Enzyme Information System"URL":
KEGG Pathways"URL":
Human Metabolome Database"URL":
  • Cell signaling and Ligand transport
  • Structural proteins

REGULATION

DIAGNOSTIC USE

Comments
2014-07-02T19:20:29 - Sabatina Liuni

BAFF signaling leads to weak stimulation of the classical NF-κB pathway as well as stimulation of the alternative NF-κB pathway. Travelling with the BAFF/BLyS family: are we there yet?,2006
Activation of these pathways leads to enhanced B-cell survival, growth and avoidance of apoptosis. 
BAFF also acts in conjunction with different interleukins such as IL-17 to propagate NF-κB–dependent B-cell survival through its ability to regulate several NF-κB proteins in the BcL-2 family as well as the activation of other NF-κB–dependent transcription factors such as Twist-1. NF-κB and systemic lupus erythematosus: examining the link., 2013
Different NF-KB transfactors activate transcription of anti-apoptotic members of the BcL-2 family, which inhibit various pro-apoptotic proteins.
Twist-1 expression is induced following B cell stimulation with IL-17 and BAFF cytokines, and is essential for naïve or memory B cell survival and proliferation as well as their differentiation into immunoglobulin producing cells. Role of TWIST proteins in cancer progression,2009

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