Aromatase
Estrogens

DEFINITION

A short protein description with the molecular wheight, isoforms, etc...
Use, when available, the link to Wikipedia (Es Trypsin)

THE GENE

Database	Link
Wikigenes	ACADM
GeneCards	"URL":
Your Favorite Gene Sigma	"URL":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

• Primary structure
• Secondary structure
• Tertiary structure
  • PDB
• Quaternary structure

Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Protein Aminoacids Percentage (Width 700 px)

SYNTHESIS AND TURNOVER

mRNA synthesis

Vitamin D

Vitamin D induces aromatase. in turn estrogens induce heme synthesys that is required for CYPs involved in VIt D activation

aromatase vitamin d
protein synthesis

• Aromatase activity of human mesenchymal stem cells is stimulated by early differentiation, vitamin D and leptin. 2006
  • Both leptin and vitamin D increased aromatase activity during osteogenesis, but not during adipogenesis;

Low serum estradiol and high serum progesterone concentrations characterize hypertensive pregnancies at high altitude. 1994

• CONCLUSIONS We speculate that reduced placental oxygen pressure (PO2) at high altitude may decrease placental aromatase activity and thereby lower estradiol and estriol concentrations.

CELLULAR FUNCTIONS

cellular localization,
biological function

• Enzymes

Database	Link
BRENDA - The Comprehensive Enzyme Information System	"URL":
KEGG Pathways	"URL":
Human Metabolome Database	"URL":

• Cell signaling and Ligand transport
• Structural proteins

REGULATION

DIAGNOSTIC USE