S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. 2019
Germinal centres are important sites for antibody diversification and affinity maturation, and are also a common origin of B cell malignancies. Despite being made up of motile cells, germinal centres are tightly confined within B cell follicles. The cues that promote this confinement are incompletely understood. P2RY8 is a Gα13-coupled receptor that mediates the inhibition of migration and regulates the growth of B cells in lymphoid tissues
Il recettore purinergico P2RY8 (P2Y receptor family member 8) si trova prevalentemente nei linfociti, ma la conoscenza del suo ruolo è appena all'inizio.
Distribuzione nei vari tipi cellulari
Significato del Geranylgeranyl-GSH
Apparentemente il Geranylgeranyl-GSH da un segnale important per il sistema immunitario nei linfonodi.
Non abbiamo prove, per ora, ma si puo' ipotizzare che dia un segnaledi ottimismo alle cellule, c'e' di tutto per il loro sviluppo
- GSH (ATP, O2, glutamate, cisteina, glicina)
- geranylgeranyle (glucoso, NADPH, FPP, GGPP, Coenzima Q10 e colesterolo)
Demolizione del geranilgeranilGSH
GGT5_HUMAN
Scinde il ledme peptidico gamma-glutamil del glutatione e glutathione-S-coniugati come il leukotriene C4 (PubMed:21447318).
May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:21447318).
Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (PubMed:30842656).
geranylgeranyl+glutathione
G-protein coupled receptors and ligands that organize humoral immune responses. 2019
Molto espresso in CD4+ e CD8+ (vedi)
