2019 Pasinato

Author: Gianpiero Pescarmona
Date: 06/03/2019


Lettura consigliata: Nutrients and Signals

Correct calf management leads to productive cows, 2017

Acido fitico: meglio avere mangimi senza o digerirlo?


Methionine as essential nutrient

Synthetic Methionine and Organic Poultry Diets, 2013


Growth Performance, Feeding Behavior and Physiological Responses of Young Growing Holstein Male Calves to Dietary Chromium-Methionine (Cr-Met) Supplementation Related to Body Weight and Age, 2018

Conflicting results. Why?


Methionine Supply During Late-Gestation Triggers Offspring Sex-Specific Divergent Changes in Metabolic and Epigenetic Signatures in Bovine Placenta.

Nonruminant male and female offspring respond differently to gestational nutrition, with placenta contributing to the underlying mechanisms. However, similar data are lacking in large ruminants.

The aim of this study was to investigate the impact of methionine supply during late-gestation on metabolism and DNA methylation in placenta from cows carrying male or female calves.

During the last 28 d of pregnancy, cows were individually fed a control diet (CON) or the control diet plus rumen-protected d,l-methionine (MET; 0.9 g/kg dry matter intake). Placentomes collected at term were classified according to cow dietary treatment and offspring sex as follows: Male CON (n = 7), Male MET (n = 7), Female CON (n = 8), and Female MET (n = 8). Calf growth was measured until 9 wk of age. Targeted metabolomics, RT-PCR, global DNA methylation, and activity of selected enzymes in one-carbon metabolism and transsulfuration pathways were performed. Statistics were conducted via ANOVA using MIXED models.

At birth, Male MET calves were heavier than Male CON calves (7.6%, P = 0.02), but body mass was similar at 9 wk of age. In contrast, compared with Female CON, Female MET calves had greater body mass at 9 wk of age (6.3%, P = 0.03). Compared with Male CON, placenta from Male MET calves had greater concentrations of tricarboxylic acid (TCA) cycle and transsulfuration intermediates (23-100%, P < 0.05), along with greater 5-methyltetrahydrofolatehomocysteine methyltransferase activity (67%, P = 0.03). Compared with Female CON, placenta from Female MET calves had greater concentrations of one-carbon metabolism intermediates (13-52%, P < 0.05). DNA methyltransferase 3A (DNMT3A) was upregulated (43%, P < 0.01) in placenta from Female MET compared with Female CON calves. Global DNA methylation was lower in placenta from Female MET compared with Female CON calves (45%, P = 0.06).

Methionine supply affects placental metabolism, DNA methylation, and body mass of the calf in a sex-specific manner, underscoring its importance as dietary methyl-donor for pregnant cows.

2019-03-08T13:26:36 - Gianpiero Pescarmona

Foods With Most Cysteine and Methionine


Life Extension Benefits of Methionine Restriction

Misleading: the heart beat rate is proportional to methionine? heart can afford higher rates with more methionine

Methionine: Functions, Food Sources and Side Effects


  • But until a friend sent me an article from Dr. Gregor’s Medical Nutrition Blog, I had no idea that many cancer cells have a metabolic defect – an absolute dependence on methionine.
    Researchers at the University of California became aware of this defect in cancer cells back in 1974. They reported that when normal and malignant cancer cells are put in a growth medium that includes methionine, only malignant cells remain in the flask after three weeks. That flask serves as the control in which the crowding out of normal cells by the malignant cells is expected.
    In contrast, if the medium contains homocystine (a methionine precursor) but no methionine, the cancer cells die. After just one week, only normal cells remain in the methionine-free flask.

How Bone Broth Balances Glycine and Methionine in Your Body

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