Author: Gianpiero Pescarmona Date: 06/03/2008
1,25-Dihydroxyvitamin D3 Increases Nuclear Vitamin D3 Receptors by Blocking Ubiquitin/Proteasome- Mediated Degradation in Human Skin-1999
In the presence cycloheximide (10 microg/ml), the liganded VDR protein was degraded with a half-life of approximately 8 h Proteasome-mediated degradation of the vitamin D receptor (VDR) and a putative role for SUG1 interaction with the AF-2 domain of VDR.1998
Etiology of Paget's disease and osteoclast abnormalities. 2004
similarities between STE3 pest and VDR
Lysine 43 or 70?
PubMed e-cadherin proteasome
Unique polyubiquitin K63-linkage-specific antibody
Distinguish K63-linked polyubiquitynilated chains
Modification of proteins by addition of K63-linked polyubiquitin chains is implicated in a variety of cellular events, including DNA repair, signal transduction and receptor endocytosis. Other lysine linkage results in different cellular mechanism (eg K48 -linked polyubiquitin proteins are degradated by 26S proteasomes).
tebu-bio is pleased to offer the first antibody able to distinguish K63-linked polyubiquitin on the market :
Introductory offer: get 15% discount off this reference until November 7th, 2008 (Please quote FRCA34-2 on your purchase order ).
Related products: Anti Ubiquitin-protein conjugates Anti Polyubiquitinylated conjugates Anti Mono- & Polyubiquitinylated conjugates Anti Mono- & Polyubiquitinylated conjugates, PO "UBIQAPTURE-Q Kit
www.tebu-bio.com : the smarter way to buy research products in Europe
