Cannabinoids action are known since 4000 years ago.
Asian culture used them not only for their effect on the SNC but they describe it as being useful for a variety of disorders including malarial fever, constipation and rheumatic pains.
It was valued, amongst other uses, for treating fevers and gastrointestinal disorders, and was used as an appetite stimulant.
Modern research is showing that cannabinoids play an important role in many different organs and this may suggest that this "old-new" molecules will play an important role in the treatment of different disease.