Urinary Exosomes
Urine Tests

Author: Gianpiero Pescarmona
Date: 24/07/2010

Description

DEFINITION

Tiny vesicles called ‘exosomes’, recently discovered in normal urine, provide a non-invasive means of acquiring unique information about the physiological or pathophysiological state of their renal cells of origin. Exosomes are delivered to the urine from all renal epithelial cell types. Consequently, analysis of urinary exosomes may provide a source of protein biomarkers for diseases involving any type of epithelial cells lining the urinary drainage tract

External links

DatabaseLink
"XYZZ":"test":
"ZXVX":"URL":

ANALYTICAL METHOD

Exosomes preparation and purification

ANALYTICAL TRICKS AND TIPS

Urinary Exosome Protein Database

THE BIOLOGICAL CONTEXT

Up to now the more studied exosomes are from:

  • Bladder Cancer
  • Prostate Cancer
  • Podocytes

The release of microvesicles from cells relies on multiple mechanisms that should be fully defined before using their measurement as a diagnostic tool.

Prostate Cancer

Senescence-associated exosome release from human prostate cancer cells. 2008

DIAGNOSTIC USE

Issues

Papers Urinary Exosomes

Specificity etc.

Diagnostic Algorithms

PROs and CONTROs

Open Questions

Working Hypothesis

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