Lipids play a preeminent role in inflammation.
Specialized pro-resolving mediators: endogenous regulators of infection and inflammation, 2015 )
Insights in the Role of Lipids, Oxidative Stress and Inflammation in Rheumatoid Arthritis Unveiled by New Trends in Lipidomic Investigations, 2021
Lipoxins
Interestingly, aspirin does not simply inhibit COX-2, but rather diverts its enzymatic activity toward the synthesis of precursors of lipoxin A4
The first step of Lipoxin A4 synthesis is shared by leukotrienes synthesis, is catalyzed by 5-LOX, and leads to LTA-4 synthesis.
Aspirin-triggered lipoxin in patients treated with aspirin and selective vs. nonselective COX-2 inhibitors. 2010
Cyclooxygenase (COX)-2 inhibition has been reported to suppress the biosynthesis of the gastroprotective lipoxygenase metabolite 15®-epi-lipoxin A4, also termed ‘aspirin-triggered lipoxin’ (ATL)
Aspirin-triggered lipoxin induces CB1-dependent catalepsy in mice. 2010
Aspirin, a non-selective COX inhibitor, acetylates COX-2 with generation of a lipoxygenase (LOX) substrate, whose end product is the 15-epi-lipoxin A(4) (15-epi-LXA), an aspirin-triggered lipoxin.
Lipoxin-Mediated Inflammatory Resolution in Newborn Hyperoxic Lung Injury
Aspirin, an anti-inflammatory drug that acetylates COX-2 and changes COX-2 function from a cyclooxygenases to a lipoxygenase, generates a more biologically stable and potent form of lipoxins, 15-epi lipoxins.
Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. 2005
COX-2-derived products increased levels of the pro-resolving lipid mediators lipoxin A4 (LXA4) and, in the presence of aspirin, 15-epi-LXA4.
Lipidomic and Transcriptome Signatures in Aspirin-Exacerbated Respiratory Disease 2009
When individuals with AERD ingest aspirin or other inhibitors of cyclooxygenase 1 they develop acute worsening of their rhinosinusitis accompanied by acute bronchoconstriction that may be life-threatening.
Induction of COX-2 by glucocorticoids + aspirin is the best anti-inflammatory combination? Dosage?
Receptors
Lipoxin and Resolvin Receptors Transducing the Resolution of Inflammation in Cardiovascular Disease, 2018
FPR2
Workshop june 2021
Workshop june 2021
Serhan Charles
