SLC11A2 (DMT1)
Iron input

Author: Gianpiero Pescarmona
Date: 03/12/2009

Description

DEFINITION

DMT1 (also known as natural resistance-associated macrophage protein 2 NRAMP2 , divalent cation transporter 1 DCT1 , or solute carrier family 11 member 2 SLC11A2 ) is a transporter involved in human iron metabolism. It is located on the apical membrane of duodenal enterocytes and transports Fe2+ from the intestinal lumen to the cytosol.

Dietary iron must be reduced from Fe3+ to Fe2+ before being transported by DMT1.

DatabaseLink
WikigenesURL
GeneCardsURL
iHOPURL
OMIMURL
Entrez GeneURL

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

  • Primary structure
  • Secondary structure
  • Tertiary structure
  • Quaternary structure

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis
post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

  • Enzymes
  • Cell signaling and Ligand transport
  • Structural proteins

REGULATION

DIAGNOSTIC USE

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