DEFINITION
A short protein description with the molecular weight, isoforms, etc...
Use, when available, the link to Wikipedia (Es Trypsin)
G-proteins
External links not available on Wikipedia have to be added here
THE GENE
CHEMICAL STRUCTURE AND IMAGES
When relevant for the function
- Primary structure
- Secondary structure
- Tertiary structure
- Quaternary structure
Protein Aminoacids Percentage (Width 700 px)
Apparently, IL-8 is a very modern protein, which was the original ligand(s)?
Viral agonists exist (The Cytomegalovirus UL146 Gene Product vCXCL1 Targets Both CXCR1 and CXCR2 as an Agonist*, 20110)
p=. 
The viral agonist is even more modern than IL-8; it uses IL-8 receptors to improve its replication. How?
SYNTHESIS AND TURNOVER
mRNA synthesis
protein synthesis
interleukin 8 and hypoxia
interleukin+8+and+mitochondria
Mitochondrial disfunction induces IL-8 synthesis
post-translational modifications
degradation
CELLULAR FUNCTIONS
cellular localization,
biological function
Interleukin-8 and human cancer biology 2001
Abstract
The aggressive nature of metastatic human cancer has been shown to be related to numerous abnormalities in growth factors and their receptors. These perturbations confer a tremendous growth advantage to the malignant cells. Interleukin-8 (IL-8), originally discovered as a chemotactic factor for leukocytes, has recently been shown to contribute to human cancer progression through its potential functions as a mitogenic, angiogenic, and motogenic factor. While it is constitutively detected in human cancer tissues and established cell lines, IL-8 expression is regulated by various tumor microenvironment factors, such as hypoxia, acidosis, nitric oxide, and cell density. Understanding the mechanisms of both inducible and constitutive IL-8 expression will be helpful in designing potential therapeutic strategies of targeting IL-8 to control tumor growth and metastasis. In this review, the role and regulation of IL-8 expression in the growth and metastasis of human cancer with a focus on human pancreatic adenocarcinoma will be discussed.
interleukin+8+and+cortisol
Do hypoxia and cortisol have similar effects?
- Cell signaling and Ligand transport
- Structural proteins
REGULATION
Human neutrophils synthesize IL-8 in an IgE-mediated activation.2004
Trifluoperazine, EGTA, reduced nicotinamide adenine dinucleotide phosphate-oxidase inhibitors, and reactive oxygen species (ROS) scavengers inhibited IL-8 production, indicating a critical dependence of calcium and oxidative stress.
Targets
S20A1_HUMAN
Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).
By phosphate deprivation as well as by IL8/interleukin-8 in hypertrophic chondrocytes
DIAGNOSTIC USE
IL+8+AND+insulin+resistance
Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men , 2003
IL+8+AND+glutathione&btnG=
Curcumin Induces Glutathione Biosynthesis and Inhibits NF-κB Activation and Interleukin-8 Release in Alveolar Epithelial Cells: Mechanism of Free Radical Scavenging Activity, 2005
cxcr1+and+cxcr2+LIGANDS
