from AMP to ATP
Nucleotides metabolism

Author: Gianpiero Pescarmona
Date: 19/04/2020

Description

The precursors

There is a cross-regulation between AMP and GMP synthesis: ATP is required for GMP synthesis and vice versa

From Monucleotide to Dinucleotide

All the 3 enzymes lack TrP pointing to a function alternative to cell proliferation (???)
From the evolutionary point of view (Glu/Gln low to high): KGUA-->KAD1 (cytoplasm)-->KAD2 (mitochondria)

AMP as a signal

In non-reproducing cells, like muscle and nerve, the balance between ATP, ADP, and AMP mainly relies on Ox-Phos activity, and an AMP increase corresponds to a low energy balance

Adenylate Kinase and AMP Signaling Networks: Metabolic Monitoring, Signal Communication and Body Energy Sensing, 2009

See AMPK

All enzymes involved in reactions from AMP to ATP have no Trp (antagonists to proliferation??)

Attachments
fileuserdate
da_AMP_a_ATP_ch1.pnggp19/04/2020
da_AMP_a_ATP_ch2.pnggp19/04/2020
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