Squamous Cell Carcinoma
Cancer

DEFINITION

Squamous cell carcinoma is a malignant tumor of epithelium that shows squamous cell differentiation. This type of cancer can be seen on the skin, lips, inside the mouth, throat or esophagus.

EPIDEMIOLOGY

age, sex, seasonality, etc

SYMPTOMS

DIAGNOSIS

histopathology
radiology
NMR
laboratory tests

PATHOGENESIS

Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-Independent growth in human tonsil epithelial cells.

HLA-DQB1*02-restricted HPV-16 E7 peptide-specific CD4+ T-cell immune responses correlate with regression of HPV-16-associated high-grade squamous intraepithelial lesions.

PATIENT RISK FACTORS

Vascular

Genetic

Association of methylenetetrahydrofolate reductase polymorphism and the risk of squamous cell carcinoma in renal transplant patients.

Acquired

Hormonal

Genetic

Acquired

TISSUE SPECIFIC RISK FACTORS

anatomical (due its structure)

vascular (due to the local circulation)

physiopathological (due to tissue function and activity)

COMPLICATIONS