Author: Gianpiero Pescarmona Date: 27/04/2007
Skin is the outer covering of the body.
Skin is composed of three primary layers:
Normal skin - low power
Normal skin - high power
Oral mucosa
Leprosy
Psoriasis
Epidermolytic Hyperkeratosis
Herpes simplex
Oral leukoplakia
The skin is an effective barrier against:
The molecular components of the barrier are:
Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier. 1997
E-Cadherin in embrio and newborn
Desmosome includes the following proteins:
Ceramide
ABCA12
It ismainly dependent on melanin synthesis by melanocytes
Hyperpigmentation caused by hyperthyroidism: differences from the pigmentation of Addison's disease. 1999
>SWISSPROT_VIRUSES:RDRP_BPSP (P09675) RNA-directed RNA polymerase beta chain (RNA replicase beta chain) [Enterobacteria phage SP] Length = 576
Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 44/94 (46%), Gaps = 18/94 (19%)
Query: 265 WFEIQTDPRTNEGILKVVKALDYEQLQSV--------------KLSIAVKNKAEFHQSVI 310 W+++ TD R++EGIL + + YE++ S+ ++ +V E QS + Sbjct: 295 WYDLLTDLRSDEGILPDGRVVTYEKISSMGNGYTFELESLIFAAIARSVCELLEIDQSTV 354
Query: 311 SRYR---VQSTPVTIQVINVREGIAFRP-ASKTF 340 S Y + T +++V E + F P KTF Sbjct: 355 SVYGDDIIIDTRAAAPLMDVFEYVGFTPNRKKTF 388
>SWISSPROT_VIRUSES:L_WWAVU (B2ZDY2) RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) [Whitewater arroyo virus] Length = 2219
Score = 29.3 bits (64), Expect = 4.4, Method: Compositional matrix adjust. Identities = 29/113 (25%), Positives = 45/113 (39%), Gaps = 17/113 (15%)
Query: 177 REQASSYRLVVSGADKDG-EGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSEL 235 RE+ Y+ + A DG T EC I + V D F + RDS + SE Sbjct: 209 REEGLDYKTKLMEAIRDGIRPNLTASECRIGIAKVYDQFCLLRDSGQYQNVYCRTSRSEM 268
Query: 236 LRFQVTDLDEEYTDNWLAVYFFTS---GNEGNWFEIQTDPRTNEGILKVVKAL 285 + WL + TS G+EG F + +L+V L Sbjct: 269 IE-------------WLKDHKLTSLINGSEGTFFNNERCGFCQNHMLRVIAEL 308
>SWISSPROT_VIRUSES:MCP_IRV16 (O39164) Major capsid protein (MCP) (P50) [Costelytra zealandica iridescent virus] Length = 462
Score = 28.1 bits (61), Expect = 9.7, Method: Compositional matrix adjust. Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 4/75 (5%)
Query: 267 EIQTDPRTNEGIL-KVVKALDYEQLQSVK-LSIAVKNKAEFHQSVISRYRVQSTPVTIQV 324 ++QT PR N L + D ++K L V+NK + S Y S VT Q Sbjct: 274 QVQTAPRQNYTPLTNAMPTFDIRFSHAIKALFFSVRNKTS--SAEWSNYATSSPVVTGQL 331
Query: 325 INVREGIAFRPASKT 339 +N AF P S T Sbjct: 332 VNYEPPGAFDPISNT 346
>SWISSPROT_FUNGI:DCL1_CRYPA (Q2VF19) Dicer-like protein 1 [Cryphonectria parasitica] Length = 1548
Score = 32.3 bits (72), Expect = 1.1, Method: Compositional matrix adjust. Identities = 24/98 (24%), Positives = 39/98 (39%), Gaps = 10/98 (10%)
Query: 111 IFMGEIEENSASNSLVMILNA--TDADEPNHLNSKIAFKIV--------SQEPAGTPMFL 160 F+G E S + +LN T +E L +K KI + P F Sbjct: 788 LFLGPVEQEMTSDLVCQVLNCPITPTEEDLQLLTKFTLKIFVDIFNKKYAANAQALPYFF 847
Query: 161 LSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLS 198 N V N D A + L AD+D E + Sbjct: 848 APTNKDHVFLFSNLQDPRNAVDWPLLRHVADRDAEAYT 885
>SWISSPROT_FUNGI:PKSL1_ASPPA (Q12053) Aflatoxin biosynthesis polyketide synthase (PKS) [Aspergillus parasiticus] Length = 2109
Score = 32.0 bits (71), Expect = 1.6, Method: Compositional matrix adjust. Identities = 17/53 (32%), Positives = 28/53 (52%), Gaps = 4/53 (7%)
Query: 353 DYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLM----IDSKTAEIKFVKNMN 401 DY+L Y ++E N+AAS V + G ++G + +D T F N N Sbjct: 1504 DYMLLDYLVLNEAENEAASGVDFSLGSSEGTFAAHPAHVDAITQVAGFAMNAN 1556
>SWISSPROT_FUNGI:HFA1_YEAS7 (A6ZMR9) Acetyl-CoA carboxylase, mitochondrial precursor (ACC) [Saccharomyces cerevisiae] Length = 2273
Score = 30.0 bits (66), Expect = 6.2, Method: Compositional matrix adjust. Identities = 23/68 (33%), Positives = 33/68 (48%), Gaps = 7/68 (10%)
Query: 310 ISRYRVQSTPVTIQVINVREGIA-FRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNK 368 S Y+++S P I + EGI F P K F V+K I+S D Q E+ K Sbjct: 1351 MSNYKIRSLPTYDSSIRIFEGISKFTPLDKRFFVRKIINSSMYND------QKTTEENLK 1404
Query: 369 AASNVKYV 376 A N + V Sbjct: 1405 AEINAQVV 1412
>SWISSPROT_FUNGI:AUS1_YEAST (Q08409) ATP-dependent permease AUS1 [Saccharomyces cerevisiae] Length = 1394
Score = 29.6 bits (65), Expect = 7.9, Method: Compositional matrix adjust. Identities = 15/50 (30%), Positives = 28/50 (56%)
Query: 334 RPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGG 383 P ++T QK I S K ++Y +GT + I + +S + +MG + G Sbjct: 738 QPITETVETQKHIISWKNINYTVGTKKLINNASGFISSGLTALMGESGAG 787
Antibodies to Saccharomyces cerevisiae in patients with Crohn's disease and their possible pathogenic importance. 1992 Raised IgA, but not IgG, yeast antibody levels were found in two patients with Crohn's disease who were intolerant to yeast, but these values were similar to those in other patients without yeast intolerance.
Glycolic Acid Treatment Increases Type I Collagen mRNA and Hyaluronic Acid Content of Human Skin, 2001