Vitamin K Supply and Metabolism
Vitamins Supply and Supplementation

Author: Gianpiero Pescarmona
Date: 01/05/2009

Description

Vitamin K denotes a group of lipophilic, hydrophobic vitamins, that are cofactors in many reactions.

This vitamin occurs naturally

Dietary deficiency is extremely rare unless the intestines are heavily damaged, are unable to absorb the molecule, or due to decreased production by normal flora, as seen in broad spectrum antibiotic use.
Synthetic vitamin K is called vitamin K3 (menadione), our body converts this vitamin into active vitamin K.

Linus Pauling Institute: Vitamin K

Structure

Chemically they are 2-methyl-1,4-naphthoquinone derivatives, that can undergo redox reactions. The side chain is composed of a varying number of isoprenoid residues.

Vitamin K shows strong similarity to Vitamin E. The structural analog Warfarin is a competitive inhibitor.

Vitamin K1

Vitamin K2

Menaquinone-n: usually n=7-9

Are menaquinones from different bacteria equivalents?

An Alternative Menaquinone Biosynthetic Pathway Operating in Microorganisms 2008

vitamin k2 and respiratory chain eukaryotes

Vitamin K3

Vitamin K3 is an alternative name of Menadione a precursor or menaquinones, that can be synthesized in humans from menadione

Papers Vitamin K3

5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization. 2010

5-hydroxy-2-methyl-1,4-naphthoquinone (plumbagin) , an analogue of vitamin K, and isolated from chitrak (Plumbago zeylanica), an Ayurvedic medicinal plant, can modulate the STAT3 pathway. We found that plumbagin inhibited both constitutive and interleukin 6-inducible STAT3 phosphorylation in multiple myeloma (MM) cells and this correlated with the inhibition of c-Src, Janus-activated kinase (JAK)1, and JAK2 activation. Vanadate, however, reversed the plumbagin-induced downregulation of STAT3 activation, suggesting the involvement of a protein tyrosine phosphatase. Indeed, we found that plumbagin induced the expression of the protein tyrosine phosphatase, SHP-1, and silencing of the SHP-1 abolished the effect of plumbagin.

Vitamin K(3) attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-kappaB activation. 2010

Dietary supplementation

FAO Recommandations

Vitamin K content in vegetables

Vitamin K supplements

Menaquinone 4

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