DEFINITION
Dynein structure 2008
Cytoplasmic dynein could be key to understanding neurodegeneration 2008
BicD and Egl associate with cargo before transport8. Cargo recognition may require additional, as yet unidentified, accessory proteins. (b) The cargo complex is recruited to the dynein–dynactin complex, at least in part, through interactions between Egl and the dynein light chain (Dlc)3. Observations in mammalian cells suggest that additional interactions between BicD and the dynein–dynactin complexes may also occur in Drosophila2, 11. © Dynein mediates minus-end-directed microtubule movement of the cargo complex. It is unclear if additional factors involved in cargo recognition remain part of the complex during transport. (d) Cargo, BicD and Egl are released from dynein at or near microtubule minus ends, whereas the dynein–dynactin complex is recycled to microtubule plus ends by kinesin-mediated transport6, 8, 12, 13. MT, microtubule.
- Kinesins complex proteins
- Dynactin complex proteins
A short protein description with the molecular wheight, isoforms, etc...
Use, when available, the link to Wikipedia (Es Trypsin)
External links not available on Wikipedia have to be added here
| Database | Link |
| Wikigenes | "DYNEIN": | "DYNACTIN": | "ACTIN 5": | "KINESIN 1": | "KINESIN 3": |
| GeneCards | "DYNEIN": | "DYNAMIN": | "ACTIN 5": | "KINESIN 1": | "KINESIN 3": |
| Entrez Gene | "DYNEIN": | "DYNACTIN": | "ACTIN 5": | "KINESIN 1": | "KINESIN 3": |
| OMIM Gene map | "DYNEIN": | "DYNACTIN": | "ACTIN 5": | "KINESIN 1": | "KINESIN 3": |
CHEMICAL STRUCTURE AND IMAGES
When relevant for the function
- Primary structure
- Secondary structure
- Tertiary structure
- Quaternary structure
Protein Aminoacids Percentage
Kinesin isoforms are very similar
Dynein isoforms are very similar
SYNTHESIS AND TURNOVER
mRNA synthesis
protein synthesis
post-translational modifications
degradation
CELLULAR FUNCTIONS
cellular localization,
biological function
- Enzymes
- Cell signaling and Ligand transport
- Structural proteins
REGULATION
Neurotropic Factors can regulate molecular motors expression
DIAGNOSTIC USE
