DEFINITION
Tiny vesicles called ‘exosomes’, recently discovered in normal urine, provide a non-invasive means of acquiring unique information about the physiological or pathophysiological state of their renal cells of origin. Exosomes are delivered to the urine from all renal epithelial cell types. Consequently, analysis of urinary exosomes may provide a source of protein biomarkers for diseases involving any type of epithelial cells lining the urinary drainage tract
External links
| Database | Link |
| "XYZZ": | "test": |
| "ZXVX": | "URL": |
ANALYTICAL METHOD
Exosomes preparation and purification
ANALYTICAL TRICKS AND TIPS
THE BIOLOGICAL CONTEXT
Up to now the more studied exosomes are from:
- Bladder Cancer
- Prostate Cancer
- Podocytes
The release of microvesicles from cells relies on multiple mechanisms that should be fully defined before using their measurement as a diagnostic tool.
Prostate Cancer
Senescence-associated exosome release from human prostate cancer cells. 2008
DIAGNOSTIC USE
Issues
Papers Urinary Exosomes
Specificity etc.
Diagnostic Algorithms
PROs and CONTROs
Open Questions
Working Hypothesis
